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Although two trials have shown that the nonsteroi- dal aromatase inhibitors anastrozole and letrozole may be supe- rior to tamoxifen in the treatment of breast. Systemic exposure to metabolites is,. Breast cancer res treat (2007) 105:7–17. Steady-state concentrations of letrozole are. Letrozole and its major human metabolite show inhibitory activity towards other cyps, but clinically relevant drug interactions seem less likely as the ki values are. The impaired metabolism of dox in patients with ckd is related to
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